AA amyloidosis (reactive systemic amyloidosis) is most commonly associated with which underlying condition?
- A Chronic inflammatory conditions such as rheumatoid arthritis or chronic infections ✓
- B Multiple myeloma with excess light chain production
- C Age-related senile cardiac amyloidosis
- D Hemodialysis-associated beta-2 microglobulin accumulation
Correct answer: A. Chronic inflammatory conditions such as rheumatoid arthritis or chronic infections
Explanation
AA amyloid is derived from serum amyloid A (SAA), an acute phase reactant produced by the liver during chronic inflammation. Prolonged elevation of SAA—as occurs in chronic RA, ankylosing spondylitis, inflammatory bowel disease, chronic osteomyelitis, or familial Mediterranean fever—leads to AA fibril deposition predominantly in kidneys, spleen, and liver. AL amyloid is associated with plasma cell dyscrasias; ATTR amyloid with senile cardiac amyloidosis; Aβ2M with dialysis.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.