In Goodpasture syndrome, the autoantibody targets a specific domain of type IV collagen. The domain targeted is the:

• A NC1 domain of the alpha3(IV) chain ✓
• B 7S domain of the alpha1(IV) chain
• C Triple helical domain of the alpha5(IV) chain
• D NC1 domain of the alpha1(IV) chain

Explanation

Goodpasture syndrome is caused by IgG autoantibodies directed against the non-collagenous 1 (NC1) domain of the alpha3 chain of type IV collagen—referred to as the 'Goodpasture antigen.' This antigen is present in the GBM and pulmonary alveolar basement membrane, explaining the dual kidney and lung involvement. Antibodies produce a linear IgG pattern on immunofluorescence. The alpha1 NC1 domain is targeted in different diseases.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.