Secondary (AA) amyloidosis deposits which precursor protein derived from the acute-phase response?
- A Immunoglobulin light chains (AL amyloid)
- B Serum amyloid A protein (SAA), an acute-phase reactant ✓
- C Transthyretin (TTR)
- D Beta-2-microglobulin
Correct answer: B. Serum amyloid A protein (SAA), an acute-phase reactant
Explanation
Secondary (reactive, AA) amyloidosis occurs in chronic inflammatory conditions (rheumatoid arthritis, TB, osteomyelitis, IBD) where sustained elevation of serum amyloid A protein, an acute-phase reactant produced by the liver, leads to its misfolding and deposition as AA amyloid fibrils predominantly in kidney, liver, and spleen. AL amyloid is derived from immunoglobulin light chains (plasma cell dyscrasias); TTR amyloid is hereditary or senile cardiac; beta-2-microglobulin amyloid complicates dialysis.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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