A 30-year-old man with MEN1 syndrome presents with recurrent peptic ulcers (Zollinger-Ellison syndrome), hypercalcemia, and visual field defects. The pituitary tumor most commonly associated with MEN1 is a:

• A Corticotroph adenoma
• B Somatotroph adenoma
• C Null cell adenoma
• D Prolactinoma ✓

Explanation

In MEN1, prolactinoma is the most common pituitary tumor, followed by somatotroph adenoma and non-functioning adenomas. Corticotroph adenomas causing Cushing disease are rare in MEN1. The classic MEN1 triad includes parathyroid hyperplasia, pancreatic neuroendocrine tumors (gastrinoma, insulinoma), and pituitary adenomas.

Reference: Williams Textbook of Endocrinology, 14th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.