A 10-year-old child presents with headaches and visual field bitemporal hemianopia. CT shows a suprasellar calcified cystic mass. Biopsy shows wet keratin nodules, peripheral palisading of nuclei, and gliosis with Rosenthal fibers. The diagnosis is:

• A Adamantinomatous craniopharyngioma ✓
• B Pituitary adenoma
• C Papillary craniopharyngioma
• D Pilocytic astrocytoma

Explanation

Adamantinomatous craniopharyngioma occurs in children, is suprasellar, calcified, and cystic. Histology shows wet keratin nodules, peripheral palisading of nuclei, gliosis with Rosenthal fibers, and 'ghost cells.' Papillary craniopharyngioma occurs in adults and lacks these features. Pituitary adenoma arises in the sella without calcification or wet keratin. Pilocytic astrocytoma lacks wet keratin and adamantinomatous features.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.