A patient with MEN1 syndrome develops a pituitary adenoma. Which of the following pituitary cell types is most commonly involved in functioning pituitary adenomas in MEN1?
- A Lactotrophs secreting prolactin (prolactinoma) ✓
- B Somatotrophs secreting growth hormone
- C Corticotrophs secreting ACTH
- D Gonadotrophs secreting FSH/LH
Correct answer: A. Lactotrophs secreting prolactin (prolactinoma)
Explanation
In MEN1 (multiple endocrine neoplasia type 1, caused by germline mutations in MENIN on chromosome 11q13), the pituitary component most commonly manifests as prolactinoma (lactotroph adenoma) — occurring in ~20-40% of MEN1 patients. The MEN1 triad is parathyroid hyperplasia (most common, causing hypercalcemia), pancreatic islet cell tumors (gastrinoma most common), and pituitary adenoma. Prolactinomas respond to dopamine agonists. GH-secreting adenomas (acromegaly) are the second most common pituitary tumor in MEN1.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.