A 55-year-old man with type 2 diabetes mellitus for 15 years undergoes renal biopsy for progressive proteinuria. Light microscopy shows nodular deposits of acellular, eosinophilic PAS-positive material in the glomerular mesangium. These deposits are eponymously named after which pathologist?
- A Virchow
- B Kimmelstiel and Wilson ✓
- C Bence Jones
- D Bowman
Correct answer: B. Kimmelstiel and Wilson
Explanation
Nodular glomerulosclerosis (Kimmelstiel-Wilson lesions) is the pathognomonic histologic finding of diabetic nephropathy. These ovoid to spherical acellular nodules expand the mesangium and represent accumulation of basement membrane-like material. They are PAS-positive and weakly silver-positive. Diffuse mesangial expansion is a more common but less specific finding in diabetic nephropathy.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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