A 60-year-old man with AIDS presents with multiple enhancing brain masses. Biopsy reveals a diffuse large B-cell lymphoma with perivascular growth. Which virus is most commonly associated with this tumor in immunocompromised patients?
- A Cytomegalovirus
- B Epstein-Barr virus ✓
- C Human herpesvirus 8
- D Human papillomavirus
Correct answer: B. Epstein-Barr virus
Explanation
Primary CNS lymphoma in immunocompromised patients is almost always associated with Epstein-Barr virus. HHV-8 is linked to primary effusion lymphoma, CMV to ventriculitis, and HPV to cervical and oropharyngeal cancers. The perivascular growth pattern is typical of CNS lymphoma.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.