A 50-year-old man presents with unilateral hearing loss and tinnitus. MRI reveals a well-circumscribed cerebellopontine angle mass. Histology shows alternating Antoni A and Antoni B areas with Verocay bodies. Which gene is most likely mutated?

• A NF1
• B VHL
• C TSC1
• D NF2 ✓

Explanation

The histology is diagnostic of schwannoma. Bilateral vestibular schwannomas are pathognomonic for neurofibromatosis type 2, caused by NF2 mutations. NF1 is associated with neurofibromas, TSC1 with tuberous sclerosis, and VHL with hemangioblastomas. The Antoni A/D pattern and Verocay bodies are characteristic of schwannoma.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.