Lewy bodies, the pathological hallmark of Parkinson's disease, are cytoplasmic inclusions containing aggregated:

• A Alpha-synuclein protein ✓
• B Tau protein in hyperphosphorylated neurofibrillary form
• C TDP-43 protein
• D Huntingtin protein with polyglutamine expansion

Explanation

Lewy bodies are eosinophilic, spherical cytoplasmic inclusions with a dense core and pale halo composed primarily of aggregated, misfolded alpha-synuclein protein. They are found in dopaminergic neurons of the substantia nigra in Parkinson's disease and in cortical neurons in Lewy body dementia. Tau aggregates form neurofibrillary tangles in Alzheimer's/PSP; TDP-43 inclusions occur in ALS/FTLD.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.