In the context of free radical-mediated cell injury, the Fenton reaction generates the highly reactive hydroxyl radical from hydrogen peroxide. Which metal ion is the essential catalyst for this reaction?
- A Iron ✓
- B Copper
- C Zinc
- D Magnesium
Correct answer: A. Iron
Explanation
The Fenton reaction requires ferrous iron (Fe2+) to catalyze the conversion of hydrogen peroxide into the highly reactive hydroxyl radical. This reaction is a major source of oxygen free radical injury in conditions like iron overload. Copper can participate in similar redox reactions, but the classic Fenton reaction specifically requires iron. Zinc and magnesium are not redox-active metals and do not catalyze this reaction.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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