After release from injured mitochondria, cytochrome c triggers formation of a cytosolic complex that activates the intrinsic apoptotic pathway. This complex consists of:

• A Cytochrome c, BCL2, BAX, and NADPH
• B Cytochrome c, RIPK3, MLKL, and ATP
• C Cytochrome c, FADD, procaspase-8, and dATP
• D Cytochrome c, Apaf-1, procaspase-9, and dATP ✓

Explanation

Cytochrome c released through BAX/BAK pores binds Apaf-1 in the presence of dATP, forming the apoptosome, which recruits and activates procaspase-9, the initiator caspase of the intrinsic pathway. Option C describes the DISC complex of the extrinsic pathway, where FADD links Fas to procaspase-8. Option B lists components of necroptosis, and BCL2 is anti-apoptotic and located on the mitochondrion, not part of this complex.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.