A liver biopsy from an alcoholic patient shows swollen hepatocytes with cytoplasmic eosinophilic inclusions composed of aggregated intermediate filaments. These inclusions are called:
- A Councilman bodies
- B Mallory-Denk bodies ✓
- C Russell bodies
- D Negri bodies
Explanation
Mallory-Denk bodies (previously Mallory bodies or alcoholic hyaline) are eosinophilic intracytoplasmic inclusions in hepatocytes composed primarily of aggregated ubiquitinated cytokeratin-8 and cytokeratin-18 intermediate filaments. They are most characteristic of alcoholic hepatitis but can be seen in non-alcoholic steatohepatitis, Wilson's disease, and primary biliary cholangitis. Councilman (acidophil) bodies are apoptotic hepatocytes shed into sinusoids in viral hepatitis; Russell bodies are immunoglobulin accumulations in plasma cells; Negri bodies are viral inclusions in neurons in rabies.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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