Metaplasia is best defined as:
- A Reversible replacement of one differentiated cell type by another ✓
- B Increased cell size without cell division in response to increased work
- C Irreversible loss of differentiation associated with malignant transformation
- D Increase in cell number by mitotic division
Correct answer: A. Reversible replacement of one differentiated cell type by another
Explanation
Metaplasia is a reversible change in which one adult cell type (epithelial or mesenchymal) is replaced by another, typically better able to withstand the altered environment. Classic examples include squamous metaplasia of bronchial epithelium in smokers and Barrett esophagus (intestinal metaplasia of esophageal squamous epithelium). If the stimulus persists, metaplasia can progress to dysplasia and malignancy. Anaplasia refers to loss of differentiation in cancer.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.