A 45-year-old man presents with progressive dyspnea and fatigue. Echocardiography reveals asymmetric septal hypertrophy with a septal thickness of 20 mm and systolic anterior motion of the mitral valve. Genetic testing reveals a mutation in a sarcomeric protein. Which of the following is the most common mode of inheritance for this condition?

• A Autosomal dominant ✓
• B Autosomal recessive
• C X-linked recessive
• D Mitochondrial inheritance

Explanation

Hypertrophic cardiomyopathy is inherited in an autosomal dominant pattern. Mutations in sarcomeric proteins such as beta-myosin heavy chain (MYH7) and myosin-binding protein C (MYBPC3) follow this inheritance. The other patterns are not characteristic of familial HCM.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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