Nonbacterial thrombotic endocarditis (NBTE, marantic endocarditis) is characteristically associated with which clinical setting?
- A Intravenous drug use causing right-sided vegetations
- B Chronic debilitating illness, malignancy, or hypercoagulable states ✓
- C Streptococcus viridans bacteremia following dental procedures
- D Acute rheumatic fever causing mitral regurgitation
Correct answer: B. Chronic debilitating illness, malignancy, or hypercoagulable states
Explanation
NBTE (marantic endocarditis) consists of sterile, bland, non-destructive vegetations along the line of valve closure, associated with hypercoagulable states, cachexia, and mucinous adenocarcinoma (especially pancreatic). The vegetations are thrombi without organisms or significant inflammatory reaction. IV drug use causes infective endocarditis preferentially on tricuspid valve; acute rheumatic fever causes verrucous endocarditis.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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