A neonate born to a mother with sickle cell trait and a father with hemoglobin C disease will most likely have which hemoglobin genotype?

• A HbSC disease ✓
• B HbSS (sickle cell disease)
• C HbCC disease
• D HbAS (sickle trait)

Explanation

Mother is HbAS (sickle trait), contributing either HbA or HbS allele. Father is HbCC, contributing only HbC allele. Offspring can be HbAC (carrier) or HbSC. HbSC disease is a clinically significant compound heterozygous hemoglobinopathy with moderate sickling and splenomegaly. HbSS would require both parents to carry HbS; HbCC requires both parents to carry HbC.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.