A 45-year-old man undergoes ORIF of a posterior wall acetabular fracture via the Kocher-Langenbeck approach. To prevent heterotopic ossification, which prophylactic measure is MOST appropriate?
- A Aspirin 325 mg daily for 6 weeks
- B Low molecular weight heparin for 4 weeks
- C Indomethacin 25 mg three times daily for 6 weeks ✓
- D Corticosteroids for 2 weeks
Correct answer: C. Indomethacin 25 mg three times daily for 6 weeks
Explanation
Indomethacin 25 mg three times daily for 6 weeks is the standard pharmacological prophylaxis against heterotopic ossification after acetabular fracture surgery, particularly via the Kocher-Langenbeck approach. Alternatively, single-dose radiation therapy (700 cGy) within 72 hours preoperatively or postoperatively can be used. The Kocher-Langenbeck approach has the highest incidence of heterotopic ossification among surgical approaches.
Reference: Rockwood and Green's Fractures in Adults, 9th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.