Prophylaxis against heterotopic ossification following total hip arthroplasty can be achieved by which of the following regimens?
- A Single fraction 8 Gy radiation within 72 hours pre-operatively or post-operatively ✓
- B Indomethacin 75 mg daily for 6 weeks post-operatively
- C Celecoxib 200 mg twice daily for 4 weeks
- D Bisphosphonate therapy for 3 months
Correct answer: A. Single fraction 8 Gy radiation within 72 hours pre-operatively or post-operatively
Explanation
Single fraction radiation therapy of 700-800 cGy (7-8 Gy) given within 72 hours before or after surgery is the standard for heterotopic ossification prophylaxis. Indomethacin 75 mg or 25 mg three times daily for 6 weeks is also effective but carries gastrointestinal and renal side effects. Celecoxib has been studied but is less established. Bisphosphonates do not prevent HO formation.
Reference: Campbell's Operative Orthopaedics, 14th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.