A 70-year-old man with long-standing gout has bilateral symmetrical hip pain with preserved joint spaces but chondrocalcinosis on X-ray. Aspiration reveals calcium pyrophosphate crystals. Which joint is most commonly affected in calcium pyrophosphate deposition disease?

• A Hip joint
• B Shoulder joint
• C First metatarsophalangeal joint
• D Knee joint ✓

Explanation

The knee is the most commonly affected joint in calcium pyrophosphate deposition disease (CPPD), followed by the wrist, metacarpophalangeal joints, and hip. CPPD can present as chondrocalcinosis on radiograph. The first MTP joint is most commonly affected in gout, not CPPD. CPPD is also associated with hemochromatosis, hyperparathyroidism, and hypomagnesemia.

Reference: Harrison's Principles of Internal Medicine, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.