Giant Cell Tumour (GCT) of bone is graded by the Campanacci radiological grading. A Grade III GCT with cortical destruction and soft tissue extension is best treated by:

• A Wide en bloc resection and reconstruction ✓
• B Extended curettage, cementing, and adjuvant (phenol/liquid nitrogen)
• C Radiotherapy as the primary modality
• D Simple curettage without cement

Explanation

Campanacci Grade III GCTs show cortical destruction with soft-tissue extension — the most aggressive pattern with high local recurrence rates (>50%) after intralesional curettage alone. For expendable bones (fibula head, distal radius, sacrum) or large aggressive lesions, wide resection with reconstruction (osteoarticular allograft, arthrodesis, or prosthesis) is preferred over curettage. For Grade I/II GCTs at joint-preserving sites, extended curettage with high-speed bur + phenol/H₂O₂/liquid nitrogen + PMMA cement is standard, with approximately 15–20% recurrence.

Reference: Maheshwari Essential Orthopaedics, 6th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.