A 70-year-old man presents with acute monoarthritis of the right knee. Synovial fluid shows weakly positively birefringent rhomboid-shaped crystals. Chondrocalcinosis is seen on X-ray. Calcium pyrophosphate deposition (CPPD) disease is diagnosed. Which metabolic condition is most strongly associated with CPPD?
- A Hyperparathyroidism ✓
- B Hypothyroidism
- C Hypouricemia
- D Wilson disease
Correct answer: A. Hyperparathyroidism
Explanation
Hyperparathyroidism is a well-recognized metabolic association of CPPD, along with hemochromatosis, hypophosphatasia, and hypomagnesemia. The association is strong enough that screening for these conditions is recommended in younger patients or those with atypical presentations. Hypothyroidism is less strongly associated. Wilson disease is linked to CPPD but is far less common.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.