A 68-year-old woman with recurrent calcium pyrophosphate deposition disease of the knee is started on prophylaxis to prevent further acute attacks. Which agent is most appropriate?
- A Allopurinol
- B Colchicine ✓
- C Probenecid
- D Febuxostat
Correct answer: B. Colchicine
Explanation
Low-dose colchicine is used for prophylaxis against recurrent attacks of pseudogout, similar to its role in gout. Allopurinol, febuxostat, and probenecid are urate-lowering therapies that target hyperuricemia and are not effective in CPPD, where the crystals are composed of calcium pyrophosphate, not urate. Colchicine inhibits neutrophil migration and the inflammatory response triggered by calcium pyrophosphate crystals, reducing the frequency of acute attacks.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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