A 55-year-old obese woman with bilateral knee osteoarthritis asks about non-pharmacological management. Which intervention has the strongest evidence for symptom relief and functional improvement?
- A Oral glucosamine sulphate
- B Copper bracelet
- C Weight loss and structured exercise ✓
- D Acupuncture
Correct answer: C. Weight loss and structured exercise
Explanation
Weight loss and structured exercise are the cornerstone of non-pharmacological management of knee osteoarthritis and have the strongest evidence for reducing pain and improving function. Glucosamine has inconsistent evidence and is not recommended by major guidelines. Copper bracelets and acupuncture have no proven benefit beyond placebo. All international guidelines, including those from the American College of Rheumatology and the National Institute for Health and Care Excellence, strongly recommend weight management and exercise.
Reference: Bailey and Love's Practice of Surgery, 28th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.