What is the standard licensed intravitreal dose of aflibercept used for diabetic macular edema?

• A 0.05 mg in 0.05 mL
• B 0.5 mg in 0.05 mL
• C 1.25 mg in 0.05 mL
• D 2 mg in 0.05 mL ✓

Explanation

Aflibercept is dosed at 2 mg in 0.05 mL for diabetic macular edema, wet age-related macular degeneration and retinal vein occlusion. Ranibizumab is 0.5 mg in 0.05 mL and off-label bevacizumab is typically 1.25 mg in 0.05 mL, which are the classic distractor pair here. Aflibercept is a soluble VEGF trap fusion protein binding VEGF-A, VEGF-B and placental growth factor, giving it a longer intravitreal half-life than the antibodies.

Reference: Kanski's Clinical Ophthalmology, 9th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.