During slit-lamp examination of a patient with granulomatous anterior uveitis, iris nodules are seen both at the pupillary margin and scattered on the anterior iris stroma away from the pupil. These two findings are respectively named:

• A Dalen-Fuchs nodules at the pupillary margin and Busacca nodules on the stroma
• B Busacca nodules at the pupillary margin and Koeppe nodules on the stroma
• C Koeppe nodules at the pupillary margin and Berlin nodules on the stroma
• D Koeppe nodules at the pupillary margin and Busacca nodules on the stroma ✓

Explanation

Koeppe nodules sit at the pupillary border and are sites of early posterior synechia formation, while Busacca nodules lie on the anterior iris stroma between the collarette and the root. Both indicate granulomatous inflammation and suggest sarcoidosis, tuberculosis, or VKH among other causes. Dalen-Fuchs nodules are histological collections of epithelioid cells beneath the retinal pigment epithelium seen in sympathetic ophthalmia and VKH, not visible as iris nodules, and there are no Berlin nodules of the iris.

Reference: Parsons' Diseases of the Eye, 23rd ed.

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Written and medically reviewed by the StethoPrep medical team.