HLA-B27 associated acute anterior uveitis is characterized by all EXCEPT:

• A Large keratic precipitates in an inferior triangular distribution ✓
• B Unilateral, acute, recurrent attacks
• C Fibrinous exudate in anterior chamber with plastic iritis
• D Association with ankylosing spondylitis, reactive arthritis, IBD

Explanation

HLA-B27 associated AAU is characterized by acute unilateral recurrent attacks with intense flare, fibrinous exudate ('plastic iritis'), and small-to-medium fine or medium keratic precipitates (KPs). Large mutton-fat KPs in an inferior triangular (Arlt's triangle) distribution are characteristic of granulomatous uveitis (sarcoidosis, tuberculosis, leprosy, sympathetic ophthalmia). HLA-B27 uveitis is non-granulomatous. It is associated with seronegative spondyloarthropathies: ankylosing spondylitis (most common association), reactive arthritis (Reiter's syndrome), psoriatic arthritis, and IBD-associated arthritis.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.