Vogt-Koyanagi-Harada (VKH) disease is a panuveitis syndrome. The PRODROMAL features before ocular inflammation begins include:

• A Alopecia, vitiligo, and poliosis appearing 2–3 months after ocular onset
• B Meningismus, headache, fever, tinnitus, and dysacusis appearing 1–2 weeks before ocular inflammation ✓
• C Joint pain and photosensitivity rash
• D Progressive bilateral hearing loss over years

Explanation

VKH disease has four phases: prodromal (meningeal irritation — headache, meningismus, dysacusis, tinnitus, fever; lasting days to weeks), acute uveitic (bilateral exudative RD, hyperaemia of disc), convalescent (integumentary: vitiligo, poliosis, alopecia, Sugiura sign), and chronic recurrent phases. The prodromal meningitic features preceding the ocular episode are characteristic and help distinguish VKH from sympathetic ophthalmia. Alopecia and vitiligo occur later in the convalescent phase, not before ocular onset.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.