Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune condition targeting melanocytes. Its ocular phase is characterized by:
- A Unilateral granulomatous anterior uveitis with iris nodules
- B Bilateral diffuse granulomatous panuveitis with exudative retinal detachments, disc edema, and choroidal thickening ✓
- C Necrotizing herpetic retinitis with retinal whitening limited to the periphery
- D Sectoral occlusive vasculitis with ischemic optic neuropathy
Correct answer: B. Bilateral diffuse granulomatous panuveitis with exudative retinal detachments, disc edema, and choroidal thickening
Explanation
VKH is a multisystem granulomatous condition targeting melanocytes in the eyes, ears, skin, and meninges. The ocular phase presents with bilateral diffuse panuveitis, exudative retinal detachments (multifocal serous retinal detachments), disc hyperemia, and choroidal thickening (seen as 'sunset glow fundus' in chronic phase). FFA shows multiple pinpoint hyperfluorescent dots with pooling of dye in the subretinal space. Systemic features include meningismus, dysacusis, vitiligo, and poliosis.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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