On fundus fluorescein angiography (FFA), a retinal pigment epithelium (RPE) detachment appears as which of the following?
- A Early hypofluorescence with late staining
- B Rapid, well-defined early hyperfluorescence that increases in size on late frames
- C Well-defined, uniform hyperfluorescence in the early phase that persists without increasing in size or leaking in late frames ✓
- D Hypofluorescence throughout all phases
Correct answer: C. Well-defined, uniform hyperfluorescence in the early phase that persists without increasing in size or leaking in late frames
Explanation
A pigment epithelial detachment (PED) on FFA demonstrates uniform, well-defined hyperfluorescence from the early arteriovenous phase that persists into late frames without enlarging (pooling pattern) and without leakage beyond the borders. This is in contrast to classic choroidal neovascularization (CNV) which leaks beyond its margins, and subretinal fluid which stains progressively. This pooling pattern distinguishes serous PED from CNV-related lesions.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.