A 45-year-old patient with proliferative diabetic retinopathy undergoes wide-field fluorescein angiography. The image shows extensive capillary non-perfusion in the mid-peripheria and neovascularization elsewhere (NVE). Which finding on FFA is the strongest indicator for panretinal photocoagulation (PRP)?
- A Capillary non-perfusion >5 disc areas ✓
- B Macular leakage
- C Venous beading
- D Microaneurysms >20 in number
Correct answer: A. Capillary non-perfusion >5 disc areas
Explanation
Extensive capillary non-perfusion (>5 disc areas) on wide-field FFA indicates significant retinal ischemia, which drives VEGF production and neovascularization. This is the strongest indication for PRP in PDR. Macular leakage requires focal laser; venous beading and microaneurysms indicate severity but do not mandate PRP alone.
Reference: Ryan's Retina, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.