Fundus autofluorescence imaging in a patient with advanced dry age-related macular degeneration shows sharply demarcated areas of hypoautofluorescence at the macula. This finding corresponds to:
- A Geographic atrophy of the retinal pigment epithelium ✓
- B Subretinal fluid
- C Drusen accumulation
- D Intraretinal lipid exudates
Correct answer: A. Geographic atrophy of the retinal pigment epithelium
Explanation
Geographic atrophy appears as sharply demarcated areas of hypoautofluorescence due to the loss of retinal pigment epithelium cells and their intrinsic lipofuscin fluorophores. Drusen typically show hyperautofluorescence. Subretinal fluid and lipid exudates do not cause sharply demarcated hypoautofluorescence on FAF imaging.
Reference: Ryan's Retina, 6th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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