A 70-year-old woman presents with a recurrent, painless upper eyelid nodule that has been incised twice as a chalazion but keeps recurring. The lid margin shows loss of meibomian gland orifices and madarosis. The most likely diagnosis is:
- A Basal cell carcinoma
- B Sebaceous gland carcinoma ✓
- C Squamous cell carcinoma
- D Malignant melanoma
Correct answer: B. Sebaceous gland carcinoma
Explanation
Sebaceous gland carcinoma frequently masquerades as a recurrent chalazion. Key clues include loss of meibomian gland orifices, madarosis, and a firm, non-tender nodule. Basal cell carcinoma presents as a nodular or ulcerated lid-margin lesion with pearly borders. Squamous cell carcinoma is scaly or ulcerated. Melanoma is pigmented.
Reference: Ophthalmic Plastic and Reconstructive Surgery, 2nd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.