Which intraocular lens design is currently favoured to minimise posterior capsule opacification (PCO) rate after cataract surgery?

• A Hydrophobic acrylic single-piece IOL with square (sharp) posterior optic edge ✓
• B Silicone single-piece lens with round anterior edge
• C PMMA three-piece IOL with round posterior edge
• D Hydrophilic acrylic lens with round posterior edge and UV filter

Explanation

The square posterior optic edge design creates a 'barrier effect' against migration of residual lens epithelial cells (LECs) onto the posterior capsule. The sharp edge produces a 360° bend in the posterior capsule, mechanically preventing LEC migration behind the optic. Hydrophobic acrylic material (e.g., AcrySof) has the lowest PCO rate among IOL materials because of its adhesive properties with the capsule and its bioincompatibility with LECs. Hydrophilic (hydrogel) lenses have higher PCO rates. The combination of hydrophobic acrylic material + sharp posterior edge gives the lowest PCO rate.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.