Posterior capsular opacification (PCO) after IOL implantation results from proliferation of which cell type, and which IOL design minimizes its occurrence?
- A Retinal pigment epithelium cells; blue light-filtering chromophore IOLs
- B Corneal endothelial cells; hydrophilic acrylic IOLs
- C Residual lens epithelial cells (LECs) migrating from the equatorial capsule; sharp posterior-edge IOL design ✓
- D Vitreous hyalocytes; IOLs with high refractive index
Correct answer: C. Residual lens epithelial cells (LECs) migrating from the equatorial capsule; sharp posterior-edge IOL design
Explanation
PCO (posterior capsule opacification, 'after-cataract') occurs due to residual lens epithelial cells (mainly equatorial E cells — Elschnig pearls, and A cells — fibrosis/anterior subcapsular opacity) migrating posteriorly across the posterior capsule. The sharp posterior optic edge of modern IOLs (e.g., AcrySof) creates a mechanical barrier that inhibits LEC migration onto the posterior capsule. Hydrophobic acrylic material also has the lowest PCO rates. Neodymium:YAG laser capsulotomy is the treatment once PCO impairs vision.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.