A patient with neovascular glaucoma secondary to central retinal vein occlusion presents with IOP of 52 mmHg and rubeosis iridis. Which pathological process is the primary cause of outflow obstruction in this condition?
- A Trabecular meshwork degeneration from chronic inflammation
- B Fibrovascular membrane causing anterior synechial angle closure ✓
- C Pupillary block from posterior synechiae
- D Ciliary body rotation closing the angle
Correct answer: B. Fibrovascular membrane causing anterior synechial angle closure
Explanation
In neovascular glaucoma, a fibrovascular membrane grows over the iris surface and trabecular meshwork, causing progressive synechial closure of the angle. This mechanical closure of the drainage angle by contracting fibrovascular tissue is the definitive mechanism. Treatment requires addressing the underlying ischaemia and lowering IOP.
Reference: Albert DM, Jakobiec FA, Principles and Practice of Ophthalmology, 3rd ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.