A 56-year-old man is newly diagnosed with primary open-angle glaucoma. According to the Glaucoma Society of India guidelines and major international trials, which is the preferred first-line topical medication?
- A Latanoprost 0.005% once daily ✓
- B Brimonidine 0.2% twice daily
- C Timolol 0.5% twice daily
- D Dorzolamide 2% twice daily
Correct answer: A. Latanoprost 0.005% once daily
Explanation
Prostaglandin analogues, particularly latanoprost, are now the preferred first-line agents for POAG in current guidelines including those adopted in India, due to superior IOP lowering (25-35%), once-daily dosing improving compliance, and favorable systemic safety profile. Beta-blockers like timolol were traditionally first-line but are now often second-line due to systemic side effects. This shift is supported by trials like the UKGTS.
Reference: The Glaucoma Book, 2010 ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.