Latanoprost lowers intraocular pressure primarily through which mechanism?
- A Increased uveoscleral outflow by remodeling extracellular matrix ✓
- B Increased conventional outflow through trabecular meshwork
- C Decreased aqueous production via ciliary epithelium beta-receptors
- D Osmotic gradient across the retina
Correct answer: A. Increased uveoscleral outflow by remodeling extracellular matrix
Explanation
Prostaglandin analogues such as latanoprost increase uveoscleral outflow by inducing matrix metalloproteinase-mediated remodeling of the ciliary muscle and scleral extracellular matrix. Beta-blockers reduce aqueous production via the trabecular meshwork and uveoscleral pathways. Carbonic anhydrase inhibitors reduce production. Miotics increase trabecular outflow. The osmotic mechanism applies to hyperosmotic agents, not latanoprost.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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