A 62-year-old man with newly diagnosed primary open-angle glaucoma also carries a diagnosis of moderately severe bronchial asthma requiring regular inhalers. Which antiglaucoma medication should be avoided in him?
- A Latanoprost
- B Timolol maleate ✓
- C Brimonidine
- D Brinzolamide
Correct answer: B. Timolol maleate
Explanation
Timolol is a nonselective beta-blocker that reduces aqueous humour production by blocking beta receptors in the ciliary processes. Systemic absorption through the nasolacrimal duct can precipitate severe bronchospasm in asthmatics, so asthma and COPD are absolute contraindications. It is also contraindicated in sinus bradycardia and atrioventricular block. Latanoprost, brimonidine and brinzolamide have no significant bronchoconstrictive effect and are safe alternatives.
Reference: Katzung's Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.