The AGIS (Advanced Glaucoma Intervention Study) demonstrated that in patients with open-angle glaucoma, the IOP level most strongly associated with halting visual field progression was:
- A < 14 mmHg at all visits with zero visits above 18 mmHg ✓
- B < 18 mmHg at all visits
- C < 21 mmHg at all visits
- D < 16 mmHg at 75% of visits
Correct answer: A. < 14 mmHg at all visits with zero visits above 18 mmHg
Explanation
The AGIS study found that patients who maintained IOP < 18 mmHg at 100% of visits (effectively near zero visits above 18 mmHg) had the greatest stability of visual fields over the 7-year follow-up. Specifically, achieving zero visits with IOP > 18 mmHg was the strongest predictor of no visual field progression, emphasizing the importance of consistent IOP control rather than average IOP alone. This established the concept of 'IOP fluctuation' as a risk factor independent of mean IOP.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.