The Collaborative Normal Tension Glaucoma Study (CNTGS) showed that a 30% reduction in IOP in normal tension glaucoma led to:
- A Reduction in visual field progression rate despite 35% of treated patients progressing ✓
- B Complete prevention of visual field progression
- C No significant difference in progression compared to untreated controls
- D Slowing only in women, not men
Correct answer: A. Reduction in visual field progression rate despite 35% of treated patients progressing
Explanation
The CNTGS demonstrated that a 30% IOP reduction reduced the rate of visual field progression from 35% (untreated) to 12% (treated) over 5 years, but a substantial proportion still progressed, indicating IOP-independent mechanisms. The study also found that cataracts developed more frequently in the treatment arm due to filtration surgery, and disc haemorrhages predicted progression independently.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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