In congenital glaucoma, the histopathological finding of Barkan's membrane refers to:

• A A fibrovascular membrane over the trabecular meshwork
• B Thickening of Schlemm's canal endothelium
• C Persistence of the tunica vasculosa lentis
• D An undifferentiated mesenchymal tissue covering the angle with failure of normal neural crest cell differentiation ✓

Explanation

Barkan's membrane is the postulated immature tissue consisting of undifferentiated neural crest cell-derived mesenchyme that covers the trabecular meshwork in congenital glaucoma, blocking aqueous outflow. Normal development involves this tissue differentiating and remodeling before birth. Goniotomy works by incising this membrane to establish a functional outflow pathway.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.