In the UKGTS (UK Glaucoma Treatment Study), the primary endpoint demonstrating neuroprotective benefit beyond IOP reduction was assessed by which method?
- A Standard automated perimetry visual field progression ✓
- B Goldmann applanation tonometry serial readings
- C Frequency-doubling technology perimetry
- D Optical coherence tomography retinal nerve fiber layer thinning rate
Correct answer: A. Standard automated perimetry visual field progression
Explanation
The UKGTS was the first trial to demonstrate that topical latanoprost reduced visual field progression (assessed by standard automated perimetry) compared to placebo over 24 months in early POAG. The trial's primary endpoint was visual field progression rate, confirming IOP lowering slows functional deterioration. OCT RNFL thinning and frequency-doubling perimetry were not the primary endpoints in UKGTS.
Reference: Khurana Comprehensive Ophthalmology, 7th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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