In the EMGT (Early Manifest Glaucoma Trial), the target IOP reduction achieved by treatment versus observation was approximately what percentage, and this was associated with a risk reduction in progression of approximately what percentage?

• A 15% IOP reduction; 35% reduction in progression risk
• B 35% IOP reduction; 60% reduction in progression risk
• C 10% IOP reduction; 20% reduction in progression risk
• D 25% IOP reduction; 50% reduction in progression risk ✓

Explanation

The EMGT demonstrated that laser trabeculoplasty plus betaxolol achieved approximately 25% IOP reduction compared to controls, which was associated with roughly 50% reduction in the risk of glaucoma progression. This landmark trial established that even in early manifest open-angle glaucoma, IOP lowering meaningfully reduces progression risk. The other options do not accurately reflect EMGT findings.

Reference: Khurana Comprehensive Ophthalmology, 7th ed.

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