Regarding the anti-D immunoglobulin administration for routine antenatal prophylaxis in Rh-negative women, which schedule is recommended by RCOG?
- A 500 IU at 28 weeks and 500 IU at 34 weeks (two-dose schedule) ✓
- B Single dose of 1500 IU at 28 weeks
- C 1500 IU at 28 weeks and 1500 IU at 34 weeks
- D A single dose of 2500 IU at 34 weeks
Correct answer: A. 500 IU at 28 weeks and 500 IU at 34 weeks (two-dose schedule)
Explanation
RCOG Green-top Guideline No. 22 recommends routine antenatal anti-D prophylaxis (RAADP) as either a two-dose schedule of 500 IU at 28 weeks and 34 weeks, or a single-dose schedule of 1500 IU at 28 weeks (both are acceptable per BCSH/RCOG). The two-dose 500 IU schedule is the classical teaching and commonly examined option. The single 1500 IU at 28 weeks is the alternative. Following delivery, if the baby is Rh-positive, a further 500 IU within 72 hours is given.
Reference: Williams Obstetrics, 26th ed.
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