A Rh-negative, antibody-negative primigravida is at 28 weeks. She has not received anti-D immunoglobulin. According to RCOG/ACOG guidelines, antenatal anti-D prophylaxis should be administered as:

• A Single dose of 1500 IU (300 µg) at 28 weeks ✓
• B Two doses of 500 IU at 28 and 34 weeks
• C Single dose of 250 IU at 28 weeks
• D Anti-D is only given postpartum if the baby is Rh-positive

Explanation

ACOG recommends a single dose of 300 µg (1500 IU) anti-D immunoglobulin at 28 weeks for antenatal prophylaxis in Rh-negative unsensitised women. The RCOG recommends either a single dose of 1500 IU at 28 weeks (RAADP — routine antenatal anti-D prophylaxis) OR two doses of 500 IU at 28 and 34 weeks. The single 1500 IU dose at 28 weeks is the most commonly tested option. Postpartum prophylaxis (within 72 hours of delivery of an Rh-positive baby) is given additionally.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.