Obstetrics & Gynaecology · Pelvic Inflammatory Disease and Genital Tuberculosis

CREST study on long-term sequelae of PID found that a single episode of PID increased the risk of ectopic pregnancy by what approximate factor?

  • A 10-fold
  • B 2-fold
  • C 6-fold
  • D 15-fold
Correct answer: A. 10-fold

Explanation

The CREST (Contraceptive and Reproductive Experiences Study) and subsequent studies demonstrated that one episode of PID increases the risk of subsequent ectopic pregnancy approximately 6–10-fold due to tubal scarring, ciliary dysfunction, and partial tubal obstruction that impairs egg transport while allowing sperm passage. After three or more episodes, infertility rates reach ~40% and ectopic risk rises further. The 10-fold increase is the classically cited figure in most major textbooks for tubal ectopic risk after PID.

Reference: Shaw's Textbook of Gynaecology, 17th ed.

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