According to the ESHRE definition adopted by Indian exam convention, premature ovarian insufficiency is diagnosed in a woman under 40 years when serum FSH exceeds which value on two occasions at least 4 to 6 weeks apart?

• A 15 IU/L
• B 20 IU/L
• C 25 IU/L ✓
• D 40 IU/L

Explanation

The ESHRE definition of premature ovarian insufficiency requires amenorrhoea or oligomenorrhoea for at least 3 months before the age of 40 years, with FSH above 25 IU/L measured on two occasions at least 4 to 6 weeks apart. A single elevated FSH is insufficient because values fluctuate during the menopausal transition. The higher figure of 40 IU/L corresponds to postmenopausal levels and is not the diagnostic threshold for POI, which makes it the tempting distractor here.

Reference: Jeffcoate's Principles of Gynaecology, 9th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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