A 16-year-old girl presents with primary amenorrhea. She has Tanner stage 1 breast development, Tanner stage 2 pubic hair, short stature (140 cm), webbed neck, and shield chest. Karyotype is 45,X. Which cardiac anomaly is most strongly associated with this condition?

• A Atrial septal defect
• B Coarctation of the aorta ✓
• C Bicuspid aortic valve
• D Mitral valve prolapse

Explanation

Turner syndrome (45,X) is classically associated with left-sided obstructive cardiac anomalies, most notably coarctation of the aorta and bicuspid aortic valve. Coarctation is the most characteristic and clinically significant cardiovascular malformation, often presenting with hypertension and requiring surgical correction. Echocardiography and cardiac MRI are mandatory at diagnosis.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.