A 26-year-old primigravida at 40+3 weeks has a Bishop score of 4. Her obstetrician plans cervical ripening. Which agent acts via prostaglandin E1 receptor agonism and is administered vaginally or sublingually for cervical ripening in an unfavourable cervix?

• A Dinoprostone
• B Mifepristone
• C Oxytocin
• D Misoprostol ✓

Explanation

Misoprostol is a synthetic prostaglandin E1 analogue that acts on EP receptors to cause cervical ripening and uterine contractions; it can be administered vaginally, sublingually, or orally. Dinoprostone is PGE2, administered as a gel or insert. Mifepristone is an antiprogestogen used for medical termination. Oxytocin acts on uterine oxytocin receptors and is less effective without cervical ripening.

Reference: Williams Obstetrics, 26th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.